Prognostic Significance of Expression of a Single MicroRNA, <i>miR-181a</i>, in Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

Abstract

To our knowledge, we provide the first evidence that the expression of a single microRNA, miR-181a, is associated with clinical outcome of patients with CN-AML and may refine their molecular risk classification. Targeted treatments that increase endogenous levels of miR-181a might represent novel therapeutic strategies.