Three‐Component Reaction Using the Bestmann–Ohira Reagent: A Regioselective Synthesis of Phosphonyl Pyrazole Rings

Abstract

BOR-n to run: A new one-pot multicomponent reaction involving the use of an aldehyde, a cyanoacid derivative, and the Bestmann–Ohira reagent (BOR) has been developed for the synthesis of substituted phosphonyl pyrazoles. This process was also combined with a copper-catalyzed azide–alkyne 1,3-dipolar cycloaddition to generate five new bonds and two heterocyclic rings in a one-pot fashion.