Asymmetric Synthesis of an Organic Compound with High Enantiomeric Excess Induced by Inorganic Ionic Sodium Chlorate

Abstract

Morphologically chiral crystals of sodium chlorate induce highly enantioselective synthesis. Thus the addition of diisopropylzinc to 2-(tert-butylethynyl)pyrimidine-5-carbaldehyde in the presence of d- and l-NaClO3 gives the (S)- and (R)-alkanol, respectively, in high yields and with high ee values (see scheme).