Association of MEGSIN 2093C–2180T haplotype at the 3′ untranslated region with disease severity and progression of IgA nephropathy

Abstract

In this Chinese population, the 2093C-2180T haplotype at the 3'UTR of MEGSIN gene is associated with more severe forms of IgAN, and more rapid disease progression. This provides further evidence for the involvement of genetic variations of MEGSIN in the pathogenesis of IgAN.