Fe-Blf Nanoformulation Targets Survivin to Kill Colon Cancer Stem Cells and Maintains Absorption of Iron, Calcium and Zinc

Abstract

Our results confirmed that NCs internalized and changed the expression of selected miRNAs that further enhanced their uptake. The NCs activated both extrinsic, as well as intrinsic apoptotic pathways to induce apoptosis by targeting survivin in cancer cells and cancer stem cells, without inducing any nonspecific nanotoxicity. Apart from inhibiting angiogenesis and stem cell markers, NCs also maintained iron and calcium levels.