Publication | Open Access
The Extra Cytoplasmic Function Sigma Factor σ <sup>E</sup> Is Essential for <i>Mycobacterium tuberculosis</i> Virulence in Mice
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Citations
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References
2004
Year
Medical MicrobiologyPulmonary TuberculosisImmunocompetent MiceVirulence FactorPathogenesisImmunologyImmune RegulationWild-type StrainHumoral ResponseTuberculosisImmune FunctionMicrobiologyInfection ControlInduced FormationMedicineCell BiologyClinical MicrobiologyHost-pathogen Interactions
The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.
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