Multifunctional Hybrid Nanoconjugates for Efficient In Vivo Delivery of Immunomodulating Oligonucleotides and Enhanced Antitumor Immunity

Abstract

A winning combination: Multifunctional hybrid nanoconjugates (HNCs) based on polymer nanoparticles containing quantum dots (QDs) conjugated with CpG oligonucleotides (as a ligand for TLR9) and STAT3 siRNAs (to suppress the immune response) have been synthesized (see scheme). These HNCs were shown to synergistically enhance the antitumor immune response in dendritic cells and in tumor-bearing mice. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.