Morphine-Induced μ-Opioid Receptor Desensitization

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

Laura Bohn, Raul R. Gainetdinov, Fang‐Tsyr Lin et al. · Nature · 2000 · 916 citations

Medicine, Neuroscience, Pharmacology +14

Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness

Jie Zhang, Stephen S. G. Ferguson, Larry S. Barak et al. · Proceedings of the National Academy of Sciences · 1998 · 511 citations

Medicine, Molecular Biology, Pharmacology +17

Functional Dissociation of μ Opioid Receptor Signaling and Endocytosis

Jennifer L. Whistler, Huai-hu Chuang, Peter C. Chu et al. · Neuron · 1999 · 417 citations · Full text

Life Sciences, Cell Biology, Neuroscience +11

Morphine-activated opioid receptors elude desensitization by β-arrestin

Jennifer L. Whistler, Mark von Zastrow · Proceedings of the National Academy of Sciences · 1998 · 372 citations · Full text

Medicine, Pharmacology, Cell Signaling +16

Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization

He Li, Jamie Fong, Mark von Zastrow et al. · Cell · 2002 · 338 citations · Full text

Medicine, Pharmacology, Cell Signaling +15