Ni0-catalyzed Direct Amination of Anisoles Involving the Cleavage of Carbon–Oxygen Bonds

Abstract

Abstract Ni0-catalyzed cross-coupling of aryl methyl ethers with amines is described. The use of an N-heterocyclic carbene as a ligand and NaOt-Bu as a base promotes the amination of anisole derivatives via the cleavage of normally unreactive aryl carbon–oxygen bonds.