Demonstration of a High Level of Parasite Population Homology by Quantification of <i>Plasmodium falciparum</i> Alleles in Matched Peripheral, Placental, and Umbilical Cord Blood Samples

Abstract

Plasmodium falciparum msp-1 and msp-2 genes were quantified by fragment analysis in matched placental, peripheral, and cord blood samples. In the three compartments, the multiplicity of infection values were similar, and parasite populations only partially overlapped, as reported. However, identical alleles represented 80 to 95% of the overall parasite populations of each compartment, demonstrating much more homogenous parasite populations than previously thought.