TGF-β1 Protects Hippocampal Neurons Against Degeneration Caused by Transient Global Ischemia

Abstract

We demonstrated that TGF-beta 1 in a surprisingly low dose range has the capacity to reduce injury to CA1 hippocampal neurons caused by transient global ischemia in rats. This protective action could well be associated with the antioxidative and antiapoptotic effects of TGF-beta 1 demonstrated in vitro.