Oral Diseases · 2011 · 37 citations · 29 references
MedicineDermatologyPathologyCutaneous OncologyDermatopathologyOral HistopathologyImmunopathology Of SkinMelanocytic LesionsMelanocytic TumorsOral NeoplasiaPigmentary DisordersSkin TumorsMalignant Melanocytic LesionsMalignant Melanocytic TumorsMelanocytic Neoplasm PathologyMelanocytic Nevus HistopathologyMelanocytic Tumor Differential DiagnosisMelanoma DiagnosisOral Melanocytic Nevus
OBJECTIVE: The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. MATERIALS AND METHODS: Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas. RESULTS: Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression. CONCLUSION: Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi.
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Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
Steven J. Kridel, Fumiko Axelrod, Natasha Rozenkrantz et al. · Cancer Research · 2004 · 601 citations · Full text
Medicine, Oncology, Pharmacology +16
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.
Sabrina Rossi, Edgard Graner, Phillip G. Febbo et al. · PubMed · 2003 · 304 citations