Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Axel T. Brünger, Paul D. Adams, G. Marius Clore et al. · Acta Crystallographica Section D Biological Crystallography · 1998 · 15.8K citations

Natural Sciences, Biophysics, Chemistry +17

AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR

Roman A. Laskowski, J.AntoonC. Rullmann, MalcolmW. MacArthur et al. · Journal of Biomolecular NMR · 1996 · 5.5K citations

Life Sciences, Biochemistry, Bioinformatics +9

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations

Medicine, Cancer Biology, Molecular Genetics +14

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

Medicine, Oncology, Pharmacology +15

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

Life Sciences, Cancer Biology, Molecular Biology +10