Reevaluation of the Combined Dexamethasone Suppression-Corticotropin-Releasing Hormone Test for Differentiation of Mild Cushing’s Disease from Pseudo-Cushing’s Syndrome

Abstract

The diagnostic performance of the DST-CRH test for the differential diagnosis between PCS and mild CD was lower than previously reported. Although the specificity of the test is improved using a revised cortisol threshold, its diagnostic accuracy is not better than that of the standard DST. Our study supports the preferential use of the DST and midnight plasma cortisol measurement as first-line diagnostic tests in equivocal cases.