Concepedia

Pharmacokinetics of pirfenidone after topical administration in rabbit eye.

Guoying Sun, Xianchai Lin, Hua Zhong, Yangfan Yang, Xuan Qiu, Chengtian Ye, Kaili Wu, Minbin Yu

PubMed · 2011 · 22 citations · 24 references

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Abstract

Measurable concentrations of pirfenidone are achieved in ocular tissues after topical application in rabbit model. Topical administration of pirfenidone may be an effective approach for modulation of wound healing responses in glaucoma filtration surgical site.

References

24

The number of people with glaucoma worldwide in 2010 and 2020

Harry A. Quigley · British Journal of Ophthalmology · 2006 · 7.3K citations · Full text

Double-blind, Placebo-controlled Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Arata Azuma, Toshihiro Nukiwa, Eiyasu Tsuboi et al. · American Journal of Respiratory and Critical Care Medicine · 2005 · 944 citations

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Treatment of Idiopathic Pulmonary Fibrosis with a New Antifibrotic Agent, Pirfenidone

Ganesh Raghu, W. Craig Johnson, Diane Lockhart et al. · American Journal of Respiratory and Critical Care Medicine · 1999 · 466 citations

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Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.

S N Iyer, G. Gurujeyalakshmi, Shri N. Giri · PubMed · 1999 · 359 citations

, , +22

Bleb-related Endophthalmitis after Trabeculectomy with Mitomycin C

Eve J. Higginbotham, Rachel Stevens, David C. Musch et al. · Ophthalmology · 1996 · 335 citations

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