Conjugation of Vitamin E Analog α-TOS to Pt(IV) Complexes for Dual-Targeting Anticancer Therapy

Abstract

We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and αTOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as promising dual-targeting anticancer agent.