The triggering of human peritoneal mesothelial cell apoptosis and oncosis by glucose and glycoxydation products

Abstract

Heat-sterilized PDFs that contain high glucose concentrations and GDPs, which are AGE precursors, reduce cell proliferation, induce mesothelial cell apoptosis and oncosis, and may be involved in peritoneal damage. PDFs containing lower glucose derivative products are more biocompatible.