Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner

TLDR

Dynamic nuclear polarization has historically been limited to particle‑physics laboratories, but recent advances enable room‑temperature liquid hyperpolarization for NMR/MRI, though physiological infusion constraints can reduce polarization. The authors present a 3.35 T DNP/9.4 T MRI system that couples a continuous‑flow cryostat with a wide‑bore low‑field NMR prepolarizer and a common radical. The system uses remote‑controlled infusion of the polarized solution into a rodent scanner and compares spin temperatures obtained with various radicals in a continuous‑flow cryostat. Data show that different radicals yield distinct spin temperatures, and the authors review the underlying DNP mechanisms that explain these differences. © 2007 Wiley Periodicals, Inc., Concepts Magn Reson Part B 31B:255–269.

Abstract

Abstract For most of the last forty years, the techniques of Dynamic Nuclear Polarization (DNP) have been confined to particle‐physics laboratories building polarized targets, but recently it has been shown that samples similar to a solid target can be transformed into room temperature liquid solutions while retaining a high nuclear polarization. This method of “hyperpolarization” is of interest in NMR/MRI/MRS. We describe a 3.35 T DNP/9.4 T MRI installation based on a continuous‐flow cryostat, using a standard wide‐bore low‐field NMR magnet as prepolarizer magnet and a widely available radical as polarizing agent. The interfacing to a rodent scanner requires that the infusion of the polarized solution in the animal be remotely controlled, because of limited access inside the magnet bore. Physiological constraints on the infusion rate can be a serious source of polarization loss, and the discussion of efficiency is therefore limited to that of the prepolarizer itself, i.e., the spin temperatures obtained in the solid state. To put our results in context, we summarize data obtained in targets with different types of radicals, and provide a short review of the DNP mechanisms needed in their discussion. © 2007 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 31B: 255–269, 2007