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Publication | Open Access

The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease

DOIFull Paper Access

43

Citations

30

References

2012

Year

Dagmar Berghuis, Marco W. Schilham, Susy J. Santos, Suvi Savola, Helen J. Knowles, Uta Dirksen, Karl‐Ludwig Schaefer, Jukka Vakkila, Pancras C.W. Hogendoorn, Arjan C. Lankester
Clinical Sarcoma Research

Abstract

Together, our results imply a crucial role for the CXCR4-CXCL12 axis in auto- and/or paracrine growth stimulation. Integration of CXCR4-targeting strategies into first- and/or second-line treatment regimens may represent a promising treatment option for Ewing sarcoma.

References

YearCitations

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