Microwave‐assisted aza‐Baylis‐Hillman Reaction. Preparation of Poly(ethylene Glycol) Supported α‐methylene‐β‐Aminoester

Abstract

Abstract The aza‐Baylis Hillman is a practical method for the preparation of α‐methylene‐β‐aminoesters. A soluble polymer supported version of this reaction has been developed. The reaction was shown to proceed in the absence of solvent under microwave activation. In the presence of 3‐hydroxyquinuclidine, the reaction time was reduced from 3–12 h under thermal conditions to 30 min under microwave irradiation. A small library of PEG‐supported aminoesters was generated.