Synthesis of conjugation-ready zwitterionic oligosaccharides by chemoselective thioglycoside activation

Abstract

A method to chemoselectively activate thioglycosides in the presence of thioethers is developed and applied in the total synthesis of repeating units of<italic>S. pneumoniae</italic>Sp1 and<italic>B. fragilis</italic>PS A1. Biochemical evaluation of these glycans is performed after conjugation to reporter moieties.