Globular and Full-Length Adiponectin Induce NO-Dependent Vasodilation in Resistance Arteries of Zucker Lean but Not Zucker Diabetic Fatty Rats

Abstract

conclusions adiponectin exerts a NO-dependent vasodilation in resistance arteries of normoglycemic ZL rats, but not diabetic ZDF rats. This may contribute to endothelial dysfunction in ZDF rats. alterations in the expression of aPPL1 may be involved in the observed insensitivity to adiponectin in ZDF rats.