Curcumin Inhibits Thrombin‐Stimulated Connective Tissue Growth Factor (CTGF/CCN2) Production Through c‐Jun NH2‐Terminal Kinase Suppression in Human Gingival Fibroblasts

Abstract

The results of this study suggest that thrombin-induced CCN2 expression may occur through PAR1, reactive oxygen species, ASK1, and JNK signaling in HGFs. Curcumin could effectively inhibit CCN2 expression through JNK suppression. These signaling events are important for wound healing and fibrosis. Additional research, including animal studies, is required to confirm the inhibiting role of curcumin in the development of gingival overgrowth.