Dynamic and Static Small-Animal SPECT in Rats for Monitoring Renal Function After ¹⁷⁷Lu-Labeled Tyr³-Octreotate Radionuclide Therapy

Abstract

Quantitative dynamic dual-isotope imaging using both (111)In-DTPA and (99m)Tc-MAG3 and static (99m)Tc-DMSA imaging in rats is feasible using small-animal SPECT, enabling longitudinal monitoring of renal function. (99m)Tc-MAG3 renography, especially, appears to be a more sensitive marker of tubular function after PRRT than serum chemistry or (99m)Tc-DMSA scintigraphy.