Oral tolerance induction to <i>Dermatophagoides pteronyssinus</i> and <i>Blomia tropicalis</i> in sensitized mice: occurrence of natural autoantibodies to immunoglobulin E

Abstract

This is the first time that the murine-type I hypersensitivity is employed to study Bt-immunization, showing a marked IgE production, associated with IgG response, which is at least in part driven by T-independent antigens. The oral tolerance protocol in previously sensitized animals was able to down-modulate IgE response and points out this route as a strategy for allergy therapy.