Palau'amine and Its Congeners: A Family of Bioactive Bisguanidines from the Marine Sponge <i>Stylotella aurantium</i>¹

Abstract

The strongly cytotoxic, antibiotic, and immunosuppressive palau'amine was isolated from the Belau sponge Stylotella aurantium, along with less active 4-bromo and 4,5-dibromo derivatives. Three corresponding isomeric compounds, all less active, were also isolated, and full details of the isolation and all structure proofs are provided.