TMEM16A/ANO1 Channels Contribute to the Myogenic Response in Cerebral Arteries

Abstract

Membrane stretch activates arterial myocyte TMEM16A channels, leading to membrane depolarization and vasoconstriction. Data also provide a mechanism by which a local Ca(2+) signal generated by nonselective cation channels stimulates TMEM16A channels to induce myogenic constriction.