Publication | Closed Access
Genetics of Regulation of Enzyme Synthesis in the Arginine Biosynthetic Pathway of Escherichia coli
138
Citations
0
References
1961
Year
GeneticsMolecular BiologyEscherichia ColiMolecular GeneticsArginine Biosynthetic PathwayGene TranscriptionEnzymatic SequenceProtein SynthesisSequence MotifBiosynthesisGene StructureRibosomal UnitPathway EngineeringBiochemistryMolecular MicrobiologyGene ExpressionFunctional GenomicsTranscription RegulationProtein BiosynthesisCellular EnzymologyNatural SciencesBiotechnologyEnzyme SynthesisParallel RepressionMicrobiologySystems BiologyMedicineMicrobial Genetics
A parallel repression of all the enzymes of a pathway has been always found whenever any endproduct repression has been observed (cf. Vogel, 1960). Moreover, in one case it has been found that the repression is not only parallel but coordinate, i.e., the enzymes of the sequence are repressed to the same extent (Ames and Garry, 1959). This behavior raises the question as to how a given repressor recognizes a given enzymatic sequence. Three possibilities are conceivable: 1) the repressor is the precursor of as many different active repressors as there are enzymes in a given pathway; 2) the repressor acts on a chromosomal or ribosomal unit responsible for the formation of all the enzymes of a sequence; 3) the enzymes of the sequence are formed by separate units but all possess a "lock" which can be operated by the same master key.