Elevated levels of leukotriene B₄ and leukotriene E₄ in bronchoalveolar lavage fluid from patients with scleroderma lung disease

Abstract

Our findings show that LTB(4) and LTE(4) levels are elevated in SSc patients with SLD and correlate with parameters of inflammation in the lungs. These results indicate that leukotrienes may contribute to the pathogenesis of SLD and may represent a new therapeutic target.