Comparison of the concentration‐dependent effect of sevoflurane on the spinal H‐reflex and the EEG in humans

Abstract

The differences in EC(50) and slope of the concentration-response relationships for H-reflex suppression and the EEG parameters point to different underlying mechanisms. In addition, the differences in time constant for equilibration between alveolar and effect compartment confirm the notion that immobility is caused at a different anatomic site than suppression of the EEG.