Chiral Phosphine Catalyzed Asymmetric Michael Addition of Oxindoles

Abstract

Bifunctional phosphines derived from amino acids mediate the asymmetric Michael addition of 3-substituted oxindoles to activated alkenes (see scheme). Biologically relevant chiral 3,3-disubstituted oxindoles were thus prepared in high yields and with excellent enantioselectivities from 3-aryl- and 3-alkyl-substituted oxindoles and various activated alkenes. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.