Abnormal Lung Development Precedes Oligohydramnios in a Transgenic Murine Model of Renal Dysgenesis

Abstract

Lethal lung hypoplasia seen at term in this model is present from the earliest stages of development, persists in vitro and, therefore, it is not consequent on renal dysfunction. These data implies that 1) fetal interventions for severe prenatal uropathies may have variable success for protecting future lung function and 2) patients with fetal uropathies may warrant greater scrutiny of prenatal lung growth and long-term postnatal lung function.