Abnormal Ventral Temporal Cortical Activity During Face Discrimination Among Individuals With Autism and Asperger Syndrome

TLDR

Face recognition is essential for social interaction, yet individuals with autism and Asperger syndrome display selective deficits in recognizing faces while preserving nonface object recognition. The study employed fMRI to compare face and object perception in 14 high‑functioning autism/Asperger participants with two matched normal control groups, defining regions of interest in one control group and applying them to the other and to the autism group in a replication design. During face discrimination, autistic participants exhibited increased right ITG and decreased right FG activation relative to controls, with a similar left‑hemisphere ITG bias in the replication, whereas controls showed greater ITG activation during object processing.

Abstract

<h3>Background</h3> Recognition of individual faces is an integral part of both interpersonal interactions and successful functioning within a social group. Therefore, it is of considerable interest that individuals with autism and related conditions have selective deficits in face recognition (sparing nonface object recognition). <h3>Method</h3> We used functional magnetic resonance imaging (fMRI) to study face and subordinate-level object perception in 14 high-functioning individuals with autism or Asperger syndrome (the autism group), in comparison with 2 groups of matched normal controls (normal control group 1 [NC1] and normal control group 2 [NC2]) (n=14 for each). Regions of interest (ROIs) were defined in NC1 and then applied in comparisons between NC2 and the autism group. Regions of interest were also defined in NC2 and then applied to comparisons between NC1 and the autism group as a replication study. <h3>Results</h3> In the first set of comparisons, we found significant task × group interactions for the size of activation in the right fusiform gyrus (FG) and right inferior temporal gyri (ITG). Post hoc analyses showed that during face (but not object) discrimination, the autism group had significantly greater activation than controls in the right ITG and less activation of the right FG. The replication study showed again that the autism group used the ITG significantly more for processing faces than the control groups, but for these analyses, the effect was now on the left side. Greater ITG activation was the pattern found in both control groups during object processing. <h3>Conclusions</h3> Individuals with autism spectrum disorders demonstrate a pattern of brain activity during face discrimination that is consistent with feature based strategies that are more typical of nonface object perception.