Asymmetric organocatalytic [3 + 2]-annulation strategy for the synthesis of N-fused heteroaromatic compounds

Abstract

Hydroxyalkyl- or aminoalkyl-substituted N-fused heteroaromatic compounds can be efficiently accessed via an organocatalytic [3 + 2]-annulation strategy. The developed cascades proceed in a highly enantioselective manner and benefit from broad substrate scope, operational simplicity, easily available starting materials as well as low catalyst loadings.