Stereocontrolled Creation of Adjacent Quaternary and Tertiary Stereocenters by a Catalytic Conjugate Addition

Abstract

Not too close for comfort: Practical chiral organocatalysts like that shown promote Michael addition reactions of a wide range of trisubstituted carbon nucleophiles to various nitroalkenes, often with nearly perfect stereoselectivity (>99 % ee and >98:2 d.r.). In one step adjacent carbon- or heteroatom-substituted quaternary and tertiary stereocenters are generated from readily available starting materials. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z461923_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.