Glycine receptor antibodies in 2 cases of new, adult-onset epilepsy

Abstract

Autoimmune encephalitides have been recognized in association with antibodies targeting neuronal surface antigen antibodies [NSAbs].1 Glycine receptors (GlyRs) are fundamental in motor neuron excitability, and antibodies against GlyRα1 (GlyR-Abs) were identified in a case of progressive encephalomyelitis with rigidity and myoclonus (PERM)2 and subsequently in other cases related to the stiff person syndrome spectrum.3