Palladium‐Catalyzed Tandem Alkenyl and Aryl CN Bond Formation: A Cascade N‐Annulation Route to 1‐Functionalized Indoles

Abstract

A single tandem operation allows rapid access to a variety of substituted N-functionalized indoles. The nitrogen atom of the indole nucleus is incorporated through Pd-catalyzed aryl and alkenyl CN bond-forming reactions (see scheme; dba=dibenzylideneacetone). Amine, aniline, amide, carbamate, and sulfonamide functional groups can be introduced efficiently.