Publication | Open Access
Pneumolysin Potentiates Production of Prostaglandin E <sub>2</sub> and Leukotriene B <sub>4</sub> by Human Neutrophils
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Citations
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References
2001
Year
Inflammatory Lung DiseaseLung InflammationImmunologyOxidative StressInflammationPneumolysin Potentiates ProductionProstaglandin EPneumococcal InfectionAllergyGranulocyteChronic InflammationAutoimmunityPharmacologyInflammatory DiseasePhagocyteInflammatory ResponsesCytokineAnti-inflammatoryMedicineHuman Neutrophils
Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.
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