Quantification of the Specific Translocator Protein Signal of ¹⁸F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding

Abstract

(18)F-PBR111 shows a high specific signal in the healthy human brain in vivo. A large component of the variability in the signal across subjects is explained by genetic variation and age, indicating that (18)F-PBR111 can be used for the quantitative assessment of TSPO expression.