Azithromycin reduces <i>Chlamydia pneumoniae</i>‐induced attenuation of eNOS and cGMP production by endothelial cells

Abstract

Infection with Cp in endothelial cells in vitro attenuates eNOS, cGMP and ROS production in HUVECs and azithromycin reverses Cp-induced effects on eNOS, cGMP and ROS-production. The results from our in vitro research support the role of antibiotic therapy for infection-induced atherosclerosis by indicating that azithromycin does actually improve endothelial function.