LXRα Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8

Abstract

This work implicates Arg1 in atherosclerosis regression and identifies LXRα as a novel regulator of Arg1 and IRF8 in macrophages. Furthermore, it provides a unique molecular mechanism by which LXRα regulates macrophage target gene expression through PU.1 and IRF8.