Role of neutrophil elastase in LTB₄‐induced neutrophil transmigration <i>in vivo</i> assessed with a specific inhibitor and neutrophil elastase deficient mice

Abstract

The findings demonstrate the potent ability of LTB(4) to induce cell-surface expression of NE and provide evidence for the involvement of NE in LTB(4)-induced neutrophil transmigration in vivo. The results also suggest the existence of compensatory mechanisms in NE(-/-) mice, highlighting the added value of investigating pharmacological blockers in parallel with genetic deletion.