Journal of Bacteriology · 2005 · 61 citations · 27 references
Life SciencesMicrobiologyMolecular BiologyBacteriologyGene ExpressionSignal TransductionBacterial Gene RegulationBacterial Secretion SystemsBacterial Virulence FactorsGene Regulation In MicrobesQuorum SensingVirulence Gene RegulationCell Density-dependent RegulationLactone BiosynthesisPositive RegulationQuorum Sensing Gene RegulationQuorum Sensing RegulationQuorum Sensing RegulatorsQuorum Sensing SignalingQuorum Sensing-regulated Virulence
BpsIR, a LuxIR quorum-sensing homolog, is required for optimal expression of virulence and secretion of exoproducts in Burkholderia pseudomallei. Cell density-dependent expression of bpsI and bpsR, the positive regulation of bpsIR expression by BpsR, and the synthesis of N-octanoyl-homoserine lactone (C8HSL) by BpsI are described in this report.
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