A <i>Let-7</i> MicroRNA SNP in the <i>KRAS</i> 3′UTR Is Prognostic in Early-Stage Colorectal Cancer

Abstract

Our results indicate that early-stage CRC cases with the KRAS-LCS6 variant have a better outcome. In advanced disease, the better outcome no longer exists. For early-stage patients, KRAS-LCS6 genotype combined with KRAS mutations merits validation as a prognostic biomarker and consideration in therapy decision-making.