Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Hisataka Yasuda, Nobuyuki Shima, N. Nakagawa et al. · Proceedings of the National Academy of Sciences · 1998 · 4.3K citations

Medicine, Cell Biology, Molecular Biology +15

Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95: 3597-602

Hisataka Yasuda, N. Shima, N. Nakagawa et al. · 1998 · 652 citations

Medicine, Endocrinology, Bone Metabolism +10

The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents.

Harold M. Frost · PubMed · 1987 · 618 citations

Natural Sciences, Orthopedic Surgery, Physiology +16

Physiology and pathophysiology of bone remodeling.

L G Raisz · PubMed · 1999 · 506 citations

Medicine, Cell Biology, Physiology +15

Skeletal structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff's Law: The remodeling problem

Harold M. Frost · The Anatomical Record · 1990 · 474 citations

Medicine, Physiology, Biomechanics +16