Bilayered Raman‐Intense Gold Nanostructures with Hidden Tags (BRIGHTs) for High‐Resolution Bioimaging

Abstract

Conventional SERS probes suffer from limited brightness and poor reproducibility and stability making them unsuitable for routine in vivo applications. A novel class of layered SERS probes is demonstrated in which individual nanostructures host electromagnetic hotspots, thus increasing brightness by more than two orders magnitude compared to conventional individual nanostructures.