The Journal of Infectious Diseases · 2009 · 71 citations · 14 references
Public HealthInfectious Disease ControlInfectious DiseasesHiv PreventionInfectious Disease EpidemiologySexual Health EducationPrevention Of Sexual TransmissionSexual HealthSexually Transmitted Infection EpidemiologySexually Transmitted Infection PreventionSexually Transmitted InfectionsViral EpidemiologyCondom Use Among Sex WorkersInfection Risk FactorsSexual Risk Behavior AssessmentSexually Transmitted Infection AssessmentSexually Transmitted Infection Risk AssessmentSyphilis EpidemiologyTransmission Risk Factors
Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878 .).
14
Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial
Ronald H. Gray, Godfrey Kigozi, David Serwadda et al. · The Lancet · 2007 · 2.2K citations