Publication | Closed Access
Anterior Pituitary Growth Hormone (STH) and Pancreatic Secretion of Glucagon (HGF).
36
Citations
0
References
1953
Year
Human GrowthPancreatic SecretionInsulin SignalingReproductive EndocrinologyPituitary GlandRecipient Dog R.Pituitary DiseaseFourteen Cross-circulation ExperimentsPublic HealthInsulin DeliveryAnimal PhysiologyGrowth HormoneEndocrine MechanismFemoral VeinEndocrinologyPharmacologyDevelopmental BiologyPhysiologyDiabetesReceptor BiologyDiabetes MellitusHyperglycemiaMetabolismMedicine
Fourteen cross-circulation experiments were performed by anastomosing the pancreatoduodenal or a mesenteric vein of a donor dog D with a femoral vein of a recipient dog R. The intravenous injection of purified anterior pituitary STH into a normal donor or into a donor previously treated with the same STH causes the appearance of a hyperglycemic material (glucagon) in the blood of the pancreatic but not of the mesenteric vein. This glucagon causes hyperglycemia in a normal recipient dog. In addition to decreasing insulin secretion (5) and inhibiting peripheral utilization of glucose (18), STH appears to cause hyperglycemia by stimulating the secretion of glucagon by the pancreas. It is believed that these results further support the hypothesis that glucagon is a pancreatic anti-insulin hormone contributing to the maintenance of a normal blood sugar concentration.