Influenza Vaccination: A Comparison of Antibody Response Obtained by Various Methods of Administration

Abstract

Summary and Conclusions Two hundred and forty-three adults and children were inoculated by the subcutaneous or interadermal routes with the combined Type A and Type B influenza virus vaccine. The rise in antibody in adults following intradermal inoculation, using 0.1 ml of vaccine, was comparable to that following subcutaneous inoculation of 0.1 ml. In adults, two intradermal inoculations of 0.1 ml each, given three days apart, did not produce antibody-rises which were significantly greater than those following a single intradermal inoculation. The antibody-rise in children, following two intradermal inoculations of 0.1 ml each, was somewhat greater than that following the same doses given subcutaneously.