Prevention of thioacetamide‐induced hepatotoxicity by biflavanones of <i>Garcinia kola</i>

Abstract

Abstract Kolaviron, a mixture of Garcinia biflavonoids GB‐1 (II‐3‐I‐4′‐II‐4″‐I‐5‐II‐5‐I‐7‐II‐7‐heptahydroxy‐3,8″‐biflavanone), GB‐2 (II‐3‐II‐3′‐I‐4′‐II‐4″‐I‐5‐II‐5‐I‐7‐II‐7‐octahydroxy‐3,8″‐biflavanone) and kolaflavanone (II‐3‐II‐3′‐II‐4″‐I‐5‐II‐5‐I‐7‐II‐7‐heptahydroxy‐3,8″‐biflavanone) obtained from Garcinia kola , protected rats against the toxic effects of thioacetamide in vivo. The biflavonoid mixture at a dose of 100mg/kg i.p. reduced the thiopental‐induced sleep in thioacetamide‐poisoned rats, both in the chronic and acute test models. The microsomal enzyme levels in the serum of rats poisoned with thioacetamide were also significantly altered by treatment with kolaviron.